Phenotype Image Detail

Image

Caption

Histological analysis of multiple organs in Atp2a1^tm1Dhm/Atp2a1^tm1Dhm newborn mice. Histological analysis of heart (A and E), lung (B and F), longitudinal sections of diaphragm (C and G), and cross-sections of diaphragm (D and H) are presented from wild-type (A-D) and Atp2a1^tm1Dhm/Atp2a1^tm1Dhm (E-H) newborn mice. Note that a lack of expression in mutant mice results in a congested and hypercellular appearance in lung (F), scattered degeneration and focal hypercontraction in diaphragm (G), and variation in diaphragm fiber size (H). Heart sections exhibit histology that is similar in newborn mice of both genotypes (A and E).

Copyright

This image is from Pan Y, J Biol Chem 2003 Apr 11;278(15):13367-75 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:82947

Associated Alleles

Symbol	Name
Atp2a1^tm1Dhm	ATPase, Ca++ transporting, cardiac muscle, fast twitch 1; targeted mutation 1, David H MacLennon

Associated Genotypes

Allelic Composition	Genetic Background
Atp2a1^tm1Dhm/Atp2a1^tm1Dhm	involves: CD-1