Phenotype Image Detail

Image

Caption

Electron microscopic analysis of diaphragm in Atp2a1^tm1Dhm/Atp2a1^tm1Dhm newborn mice. A: Longitudinally oriented diaphragm muscle demonstrating a region of normal myofiber alignment immediately adjacent to a region of hypercontraction. In the regions of hypercontraction, the distance between Z-bands was ~1.3 um compared with about 2 um in the normally contracted regions. Note the prominence of the Z-bands within the regions of hypercontraction. B: An enlargement of a longitudinally oriented myofiber with marked hypercontraction, prominent Z-bands, complete overlap of thick and thin filaments, and intrusion of filaments into the Z-band region.

Copyright

This image is from Pan Y, J Biol Chem 2003 Apr 11;278(15):13367-75 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:82947

Associated Alleles

Symbol	Name
Atp2a1^tm1Dhm	ATPase, Ca++ transporting, cardiac muscle, fast twitch 1; targeted mutation 1, David H MacLennon

Associated Genotypes

Allelic Composition	Genetic Background
Atp2a1^tm1Dhm/Atp2a1^tm1Dhm	involves: CD-1