Phenotype Image Detail

Image

Caption

Perinatal gross morphology demonstrates tortuous aorta and diaphragmatic rupture in Lox^tm1Ikh/Lox^tm1Ikh mice. A and B: Anterior surface of wild-type (+/+, A) and mutant (-/-, B) mice. Necropsy was performed by dissection of the skin, ribs and peritoneum and photomicrographs (x10) of the anterior surface are displayed. H, heart; Lu, lungs; L, liver; Dia, diaphragm (arrows pointing to diaphragm); S, stomach. Note the diaphragm rupture with abdominal contents filling the thorax in mutant. C and D: Posterior thorax of the wild-type (C) and mutant (D) mice. Following necropsy, photomicrographs (x10) of the anterior surface of the posterior chest wall are displayed. The thoracic aorta is indicated with arrows marking the right and left sides. Note the tortuousity of the mutant aorta with maximal displacement to the right and left indicated by arrows.

Copyright

This image is from Hornstra IK, J Biol Chem 2003 Apr 18;278(16):14387-93 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:82926

Associated Alleles

Symbol	Name
Lox^tm1Ikh	lysyl oxidase; targeted mutation 1, Ian K Hornstra

Associated Genotypes

Allelic Composition	Genetic Background
Lox^tm1Ikh/Lox^tm1Ikh	involves: 129X1/SvJ * C57BL/6J