Phenotype Image Detail

Image

Caption

A-C: Anti-Phgdh immunofluorescent-stained sagittal sections of wild-type (+/+, A) and Phgdh^tm1.1Shfu/Phgdh^tm1.1Shfu (-/-, B, C) embryos show the complete elimination of Phgdh protein in the brains of mutant embryos. D and E: TuJ1 and anti-GLAST immunostaining highlights noticeably reduced masses of both TuJ1-positive neuronal (green) and GLAST-positive neuroepithelial/radial glial (red) populations in the primordial plexiform layer (PPL) and ventricular zone (VZ) of Type I (H) and Type II (G and J) mutant embryos. Arrowheads in F and G indicate regions of the cerebral cortex shown in I and J at a higher magnification. Abbreviation: LV, lateral ventricle. Scale bars: A-C and F-G, 1mm; D and E, 100um; I and J, 50um.

Copyright

This image is from Yoshida K, J Biol Chem 2004 Jan 30;279(5):3573-7 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:128777

Associated Alleles

Symbol	Name
Phgdh^tm1.1Shfu	3-phosphoglycerate dehydrogenase; targeted mutation 1.1, Shigeki Furuya

Associated Genotypes

Allelic Composition	Genetic Background
Phgdh^tm1.1Shfu/Phgdh^tm1.1Shfu	involves: 129P2/OlaHsd * C57BL/6J * FVB/N
Phgdh^tm1.1Shfu/Phgdh^tm1.1Shfu	B6.129P2(FVB)-Phgdh^tm1.1Shfu