Phenotype Image Detail

Image

Caption

Microscopic overview of the skin from the back of an Elovl3^tm1Jaco/Elovl3^tm1Jaco mouse (A-E) and wild-type mouse (F-J) at the age of 9 weeks showing epidermis, hair follicles, and dermis. A: In the mutant mouse, the normal hair is missing in the upper part of several hair follicles though the hair seems normal in the lower parts. B: In higher magnification, an increased thickness of the epidermis and hypergranulation is seen both in epidermis and in the hair follicle. C: Transverse section of a hair follicle shows abnormal epithelial cells. D: The inner cell layer of the outer root sheath appears abnormal with irregularly shaped nuclei (arrows). E: Hyperplastic and enlarged sebocytes are seen in the sebaceous glands. G: By in situ hybridization very low Elovl3 expression is seen in a cross-section of epidermis of wild-type skin. H: Horizontal section showing specific expression of Elovl3 in the epithelial cells of a hair follicle (arrow, black grains). I: A higher magnification of the epithelial cells of the hair follicle showing abundant Elovl3 mRNA signal in the cells of the inner layer of the outer root sheath (ORS) of the hair follicle (arrows). IRS, inner root sheath. J: A strong Elovl3 mRNA signal (black grains) was detected in normal sebocytes. A-E: No Elovl3 mRNA signal was detected in mutant mice. (All sections are counterstained with hematoxylin and eosin).

Copyright

This image is from Westerberg R, J Biol Chem 2004 Feb 13;279(7):5621-9 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:88477

Associated Alleles

Symbol	Name
Elovl3^tm1Jaco	ELOVL fatty acid elongase 3; targeted mutation 1, Anders Jacobsson

Associated Genotypes

Allelic Composition	Genetic Background
Elovl3^tm1Jaco/Elovl3^tm1Jaco	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J