Phenotype Image Detail

Image

Caption

Vascular development in S1p receptor mutant embryos. Whole-mount immunohistochemical staining was performed with rat anti-CD31 (PECAM-1) monoclonal antibody on the following E10.5 embryos: wild-type (WT, A and B); S1pr1^tm1Rlp/S1pr1^tm1Rlp (C and D); S1pr1^tm1Rlp/S1pr1^tm1Rlp S1pr2^tm1Rlp/S1pr2^tm1Rlp double null (E and F); and S1pr1^tm1Rlp/S1pr1^tm1Rlp S1pr2^tm1Rlp/S1pr2^tm1Rlp S1pr3^tm1Rlp/S1pr3^tm1Rlp triple null (G and H). Panels A,C,E and G offer whole body views. Panels B,D,F and H show close-up views of head vessels. The white lines in panels A,C,E and G indicate the head regions views in panels B,D,F and H). Arrows indicate branch points in the vessels.

Copyright

This image is from Kono M, J Biol Chem 2004 Jul 9;279(28):29367-73 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:106055

Associated Alleles

Symbol	Name
S1pr1^tm1Rlp	sphingosine-1-phosphate receptor 1; targeted mutation 1, Richard L Proia
S1pr2^tm1Rlp	sphingosine-1-phosphate receptor 2; targeted mutation 1, Richard L Proia
S1pr3^tm1Rlp	sphingosine-1-phosphate receptor 3; targeted mutation 1, Richard L Proia

Associated Genotypes

Allelic Composition	Genetic Background
S1pr1^tm1Rlp/S1pr1^tm1Rlp S1pr2^tm1Rlp/S1pr2^tm1Rlp	involves: 129S6/SvEvTac * C57BL/6
S1pr1^tm1Rlp/S1pr1^tm1Rlp S1pr3^tm1Rlp/S1pr3^tm1Rlp S1pr2^tm1Rlp/S1pr2^tm1Rlp	involves: 129S6/SvEvTac * C57BL/6