Phenotype Image Detail

Image

Caption

Abnormalities in angiogenesis are evident in the placenta of Med1^tm1Jkr/Med1^tm1Jkr (PBP-/-, B) embryos, where the rich capillary network observed in the wild-type (WT, A) had failed to develop. Unlike the placental anomaly, the mutant embryos had excessive vascularization especially along the paraspinal region (arrows, D) when the controls were compared (C). Sections A and B were stained with hematoxylin and eosin.

Copyright

This image is from Crawford SE, J Biol Chem 2002 Feb 1;277(5):3585-92 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:74328

Associated Alleles

Symbol	Name
Med1^tm1Jkr	mediator complex subunit 1; targeted mutation 1, Janardan K Reddy

Associated Genotypes

Allelic Composition	Genetic Background
Med1^tm1Jkr/Med1^tm1Jkr	involves: 129P2/OlaHsd * C57BL/6