Phenotype Image Detail

Image

Caption

Phenotype of Fbxw7^tm1Kin/Fbxw7^tm1Kin embryos. A-C: Gross appearance of wild-type (Fbw7^+/+, A) and Fbxw7^tm1Kin/Fbxw7^tm1Kin (Fbw7^-/-, B and C) embryos at E10.5. Arrows in B and C indicate hemorrhage in the head region. D-G: Whole mount immunohistochemical analysis with anti-PECAM-1 of the head region (D and E) and yolk sac (F and G) of E10.5 embryos. Mutant embryos (E and G) exhibited a disorganized vasculature compared with the fine vascular network of wild-type embryos (D and F). Arrows and arrowhead in D indicate head veins and the internal carotid artery, respectively. H and I: Immunohistochemical staining with anti-PECAM-1 of wild-type (H) and mutant (I) embryos at E9.5. Arrowheads in I indicate the absence of anterior cardinal veins in mutant embryos. Abbreviations: nt, neural tube; acv, anterior cardinal vein; da, dorsal aorta; at, atrium. Scale bars: A-C, F and G, 500um; D and E, 250um; H and I, 100um.

Copyright

This image is from Tsunematsu R, J Biol Chem 2004 Mar 5;279(10):9417-23 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:88517

Associated Alleles

Symbol	Name
Fbxw7^tm1Kin	F-box and WD-40 domain protein 7; targeted mutation 1, Kei-ichi Nakayama

Associated Genotypes

Allelic Composition	Genetic Background
Fbxw7^tm1Kin/Fbxw7^tm1Kin	involves: C57BL/6