Phenotype Image Detail

Image

Caption

Caveolin-3 protein expression is required for the development of a mature highly organized T-tubule system. Skeletal muscle tissue samples from wild-type mice (Cav-3 WT, A, left panel) and Cav3^tm1Mls/Cav3^tm1Mls (Cav-3 KO, A, right panel) were subjected to T-tubule system staining using potassium ferrocyanate. As a consequence, the T-tubules appear as electron-dense structures (stained black). Note that the T-tubule system is dilated and longitudinally oriented in mutant mice. Transmission electron micrographs of skeletal muscle sections from mutant mice are also shown in panel B at a higher magnification.

Copyright

This image is from Galbiati F, J Biol Chem 2001 Jun 15;276(24):21425-33 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:69965

Associated Alleles

Symbol	Name
Cav3^tm1Mls	caveolin 3; targeted mutation 1, Michael P Lisanti

Associated Genotypes

Allelic Composition	Genetic Background
Cav3^tm1Mls/Cav3^tm1Mls	involves: 129/Sv * C57BL/6J * SJL
Cav3^tm1Mls/Cav3^tm1Mls	FVB.Cg-Cav3^tm1Mls