Phenotype Image Detail

Image

Caption

Embryos from Loricrin^tm1Der/Lor⁺ (+/-) intercrosses were extracted with methanol, which is thought to partially extract polar lipids, and stained with toluidine blue. Staining indicates permeability for the dye and shows immature barrier function. The approximate age of the embryos and their genotype is indicated. At E16.5 heterozygous embryos showed large unstained areas on the back skin, whereas the Loricrin^tm1Der/Loricrin^tm1Der (-/-) embryos were completely stained, indicating a delay in the formation of the skin barrier in these embryos. Wild-type (+/+) and heterozygous embryos showed a similar staining pattern (data not shown). At E17.5, mutant and wild-type (data not shown) embryos were largely unstained.

Copyright

This image is from Koch PJ, J Cell Biol 2000 Oct 16;151(2):389-400, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:65187

Associated Alleles

Symbol	Name
Loricrin^tm1Der	loricrin cornified envelope precursor protein; targeted mutation 1, Dennis R Roop

Associated Genotypes

Allelic Composition	Genetic Background
Loricrin^tm1Der/Loricrin^tm1Der	FVB.129S7-Loricrin^tm1Der