Phenotype Image Detail

Image

Caption

Gross abnormalities in newborn Loricrin^tm1Der/Loricrin^tm1Der mice. Top: Comparison of Loricrin^tm1Der/Loricrin^tm1Der (top pup) and wild-type (bottom pup) newborn mouse. Mutant mice were born with a shiny, translucent skin. Bottom: This phenotype disappeared in older mice. Adult mutant (top) and wild-type (bottom) mice were indistinguishable.

Copyright

This image is from Koch PJ, J Cell Biol 2000 Oct 16;151(2):389-400, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:65187

Associated Alleles

Symbol	Name
Loricrin^tm1Der	loricrin cornified envelope precursor protein; targeted mutation 1, Dennis R Roop

Associated Genotypes

Allelic Composition	Genetic Background
Loricrin^tm1Der/Loricrin^tm1Der	FVB.129S7-Loricrin^tm1Der
Loricrin^tm1Der/Loricrin^+	FVB.129S7-Loricrin^tm1Der
Loricrin^tm1Der/Loricrin^tm1Der	involves: 129S7/SvEvBrd