Phenotype Image Detail

Image

Caption

Skull development in Gja1^tm1Kdr/Gja1^tm1Kdr embryos. A and B: Lateral view of the skull of alizarin red/alcian blue-stained E16.5 wild-type (WT) and Gja1^tm1Kdr/Gja1^tm1Kdr (Cx43(-/-)) embryos. C and D: Dorsal, E and F: ventral, and G and H: lateral views of the skull of alizarin red-stained E18.5 (C,E and G) wild-type and (D,F and H) mutant embryos. G and H: Lateral view on the skull at E18.5 shows the incipient mineralization of parietal, nasal, frontal and squamous parts of the temporal bones in mutant mice, though all these elements remain developmentally hypomineralized, especially around their rostral boundaries. F, frontal bone; P, parietal bone; S, squamous part of the temporal bone; I, interparietal bone; E, exoccipital bone; M, mandible; T, tympanic ring; PL, palatine bone; PT, pterygoid bone; BS, basisphenoid bone; AS, alisphnoid bone; and BO, basioccipital bone.

Copyright

This image is from Lecanda F, J Cell Biol 2000 Nov 13;151(4):931-44, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:65866

Associated Alleles

Symbol	Name
Gja1^tm1Kdr	gap junction protein, alpha 1; targeted mutation 1, Gerald M Kidder

Associated Genotypes

Allelic Composition	Genetic Background
Gja1^tm1Kdr/Gja1^tm1Kdr	involves: 129S1/Sv * 129X1/SvJ * C57BL