Phenotype Image Detail

Image

Caption

Skull development in Gja1^tm1Kdr/Gja1^tm1Kdr mice at birth. A and B: Lateral views and, C and D: Dorsal views of the cranial vault at birth of wild-type (WT, A and C) and Gja1^tm1Kdr/Gja1^tm1Kdr (Cx42^-/-, B and D) littermates at birth. Note the prominent cartilagenous primordia of the occipital bone in the homozygous mutants, whereas the parietal, interparietal, and supraoccipital bones are thinner and less developed, allowing a direct view of the cranial base. A ventral view of the cranial base of wild-type (E) and mutant (F) littermates at birth. The horizontal laminae of the palatine bones were slightly smaller, and the alisphenoid was misshapen, leaving a larger unmineralized area delimited by the palatine, alisphenoid, and temporal bones. The horizontal portion of the palatine bones and the palatine processes of the maxilar bone, collectively referred to as palatal shelves were present. The tympanic ring was reduced in size and thinner. The jugal bone of the zygomatic arch was shorter, resulting in a misshapen zygomatic arch. Overall, the nasal and maxillary bones were slightly smaller, resulting in a more pointed and smaller snout in the mutant mice. J, jugal part of the zygomatic bone; F, frontal bone; P, parietal bone; S, squamous part of the temporal bone; I, interparietal bone; E, exoccipital bone; M, mandible; T, tympanic ring; PL, palatine bone; PT, pterygoid bone; BS, basisphenoid bone; AS, alisphenoid bone; BO, basioccipital bone.

Copyright

This image is from Lecanda F, J Cell Biol 2000 Nov 13;151(4):931-44, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:65866

Associated Alleles

Symbol	Name
Gja1^tm1Kdr	gap junction protein, alpha 1; targeted mutation 1, Gerald M Kidder

Associated Genotypes

Allelic Composition	Genetic Background
Gja1^tm1Kdr/Gja1^tm1Kdr	involves: 129S1/Sv * 129X1/SvJ * C57BL