Phenotype Image Detail

Image

Caption

Axial development in Gja1^tm1Kdr/Gja1^tm1Kdr embryos. Lateral view of the thoracic vertebrae stained with alizarin red/alcian blue of E15.5 (A and B) and E16.5 (C) wild-type (WT, A and D) and Gja1^tm1Kdr/Gja1^tm1Kdr (Cx43^-/-, B,C and D) mice. B and C: Note the delayed ossification of the vertebrae and ribs and the thinner and deformed ribs in the mutant mice. Posterior view of the head and thorax of alizarin red-stained wild-type (D) and mutant (E) embryos at E18.5 showing a similar ossification of the vertebrae, limbs and exoccipital bones, but delayed ossification of the parietal, interparietal, and supraoccipital bones. Note that the two ossification centers of the supraoccipital bone have not fused in the mutant.

Copyright

This image is from Lecanda F, J Cell Biol 2000 Nov 13;151(4):931-44, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:65866

Associated Alleles

Symbol	Name
Gja1^tm1Kdr	gap junction protein, alpha 1; targeted mutation 1, Gerald M Kidder

Associated Genotypes

Allelic Composition	Genetic Background
Gja1^tm1Kdr/Gja1^tm1Kdr	involves: 129S1/Sv * 129X1/SvJ * C57BL