Phenotype Image Detail

Image

Caption

The fourth pairs of mammary glands from wild-type (A,C and E) or Ncoa6^tm1Jkr/Ncoa6^tm1Jkr Tg(MMTV-cre)FMam/? (B,D and F) mice on the 8th day of lactation were isolated and then whole-mounted or fixed for hematoxylin and eosin section. Whole-mount revealed that mutant glands (B) contained fewer and smaller lobuloalveoli than wild-type glands (A). C and D represent higher magnification of the lobuloalveolar structures in A and B, respectively. On hematoxylin and eosin section, mutant glands (F) showed abundant adipocytes surrounding alveoli, whereas wild-type glands (E) contained well developed alveoli with no recognizable adipocytes.

Copyright

This image is from Qi C, J Biol Chem 2004 Aug 6;279(32):33696-701 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:121207

Associated Alleles

Symbol	Name
Ncoa6^tm1Jkr	nuclear receptor coactivator 6; targeted mutation 1, Janardan K Reddy
Tg(MMTV-cre)FMam	transgene insertion F, Lothar Hennighausen

Associated Genotypes

Allelic Composition	Genetic Background
Ncoa6^tm1Jkr/Ncoa6^tm1Jkr Tg(MMTV-cre)FMam/?	involves: 129P2/OlaHsd * FVB