Phenotype Image Detail

Image

Caption

Attenuated response of Ncoa6^tm1Jkr/Ncoa6^tm1Jkr Tg(MMTV-cre)FMam/? glands to estrogen treatment. Five week old wild-type or Ncoa6^tm1Jkr/Ncoa6^tm1Jkr Tg(MMTV-cre)FMam/? females were ovariectomized and implanted with estrogen pellets under the skin behind the neck. Three weeks later, the fourth pair of mammary glands was isolated, fixed, and whole-mounted. Note the difference in the number of ductal branches between wild-type mammary glands (A) and mutant mammary glands (B). C and D represent higher magnification of the ductal structures in A and B, respectively.

Copyright

This image is from Qi C, J Biol Chem 2004 Aug 6;279(32):33696-701 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:121207

Associated Alleles

Symbol	Name
Ncoa6^tm1Jkr	nuclear receptor coactivator 6; targeted mutation 1, Janardan K Reddy
Tg(MMTV-cre)FMam	transgene insertion F, Lothar Hennighausen

Associated Genotypes

Allelic Composition	Genetic Background
Ncoa6^tm1Jkr/Ncoa6^tm1Jkr Tg(MMTV-cre)FMam/?	involves: 129P2/OlaHsd * FVB