Phenotype Image Detail

Image

Caption

Cell proliferation and apoptosis in terminal end buds of wild-type and Ncoa6^tm1Jkr/Ncoa6^tm1Jkr Tg(MMTV-cre)FMam/? mice. A and B: Six week old mice were injected with BrdUrd and iguinal mammary glands were prepared, fixed and sectioned and stained with anti-BrdUrd. No difference in cell proliferation was observed between wild-type (A) and Ncoa6^tm1Jkr/Ncoa6^tm1Jkr Tg(MMTV-cre)FMam/? (B) mammary glands. C and D: Immunohistochemistry was performed on mammary gland sections to detect TUNEL-positive cells undergoing apoptosis. Note the increased appotosis in terminal end buds from mutant glands (D) as compared with those from wild-type mammary glands (C).

Copyright

This image is from Qi C, J Biol Chem 2004 Aug 6;279(32):33696-701 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:121207

Associated Alleles

Symbol	Name
Ncoa6^tm1Jkr	nuclear receptor coactivator 6; targeted mutation 1, Janardan K Reddy
Tg(MMTV-cre)FMam	transgene insertion F, Lothar Hennighausen

Associated Genotypes

Allelic Composition	Genetic Background
Ncoa6^tm1Jkr/Ncoa6^tm1Jkr Tg(MMTV-cre)FMam/?	involves: 129P2/OlaHsd * FVB