Phenotype Image Detail

Image

Caption

EM analysis of longitudinally sectioned optic nerves from adult Mal^tm1Nsw/Mal^tm1Nsw (KO) mice revealed numerous disorganized paranodes with everted paranodal loops not adhering to the axon (B,D,E; arrow in B). In wild-type mice, normal paranodal loop organization was observed (A and C). Transverse bands were regularly detected in wild-type mice (C, arrowheads), whereas in mutant mice transverse bands were usually present but less organized (D and E, arrowheads), or absent under some of the paranodal loops (D, arrow). In the paranode in D, there is only one loop with normal septate-like junctions (arrowheads), whereas the adjacent loops lack intact septa. Analysis of longitudinal sections of optic nerves from P20 wild-type mice (F) revealed intact paranodes with normal transverse bands (F, arrowheads). Optic nerves of age-matched mutant (G), in contrast, contained numerous disorganized paranodes with everted paranodal loops and irregular transverse bands (G, arrowheads). Bars: A, 1 m; B, 0.5 m; C, 0.2 m; D, 0.2 m; E, 0.25 m; F and G, 0.1 m.

Copyright

This image is from Schaeren-Wiemers N, J Cell Biol 2004 Aug 30;166(5):731-42, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported LicenseJ:92517

Associated Alleles

Symbol	Name
Mal^tm1Nsw	myelin and lymphocyte protein, T cell differentiation protein; targeted mutation 1, Nicole Shaeren-Wiemers

Associated Genotypes

Allelic Composition	Genetic Background
Mal^tm1Nsw/Mal^tm1Nsw	involves: 129P2/Ola