Phenotype Image Detail

Image

Caption

Haif follicle analysis. Histology is similar at P2 (A and B) but by P6, Sgk3^tm1Okad/Sgk3^tm1Okad (KO) follicles are smaller and fail to grow down to the bottom of the subcutis (C and D). At P6, the shortened mutant bulb has a smaller, rounded dermal papilla (DP) relative to the long, thin DP of wild-type (WT) follicles (G and H). Apoptotic cells are seen in some mutant follicles bulbs (J and K); although many P6 bulbs show no apoptotic cells, some have as many as six. Incorporation of BrdU in mutant bulbs at P6 is reduced relative to wild-type bulbs (L-O). Arrows represent examples of BrdU-positive nuclei. I: Quantification shows that total cell number is reduced in mutant bulbs at P6, apoptotic cell number is increased, and proliferation is markedly decreased. Epi, epidermis; De, dermis; SubQ, subcutis; Mx, matrix; Mg, melanin granules; TEM, transmission EM; AP, alkaline phosphatase. Bars: A-D, 100 um; E-H and L-O, 20 um; J and K, 10 um.

Copyright

This image is from Alonso L, J Cell Biol 2005 Aug 15;170(4):559-70, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:100992

Associated Alleles

Symbol	Name
Sgk3^tm1Okad	serum/glucocorticoid regulated kinase 3; targeted mutation 1, Hitoshi Okada

Associated Genotypes

Allelic Composition	Genetic Background
Sgk3^tm1Okad/Sgk3^tm1Okad	involves: 129P2/OlaHsd