Phenotype Image Detail

Image

Caption

A: Morphological analysis of Chmp5^tm1Gho/Chmp5^tm1Gho embryos. Lateral view of wild-type (+/+) embryos and mutant (-/-) littermates at E7.5, E7.75, E8.5, and E9.25. B: Lateral, front and ventral view of E8.75 mutant embryos. The yolk sac was removed from the embryos. Al, allantois; Am, anmion; Hf, head fold; M, midline. C: Histological analysis of E8.5 mutant embryos. Ht, heart; S, somite. D: Abnormal heart formation in mutant embryos revealed by whole-mount in situ hybridization with the cardiac marker Nkx2.5. (top) Arrows and arrowhead indicate heart tissue. Masive cell death in mutant embryos revealed by TUNEL staining of E8.5 embryos. (bottom) Arrow indicates apoptotic cells. Bars: C, 50 um; D, 100 um.

Copyright

This image is from Shim JH, J Cell Biol 2006 Mar 27;172(7):1045-56, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:107913

Associated Alleles

Symbol	Name
Chmp5^tm1Gho	charged multivesicular body protein 5; targeted mutation 1, Sankor Ghosh

Associated Genotypes

Allelic Composition	Genetic Background
Chmp5^tm1Gho/Chmp5^tm1Gho	involves: 129S6/SvEvTac * C57BL/6