Phenotype Image Detail

Image

Caption

Lack of increased intestinal apoptosis or basement membrane disruption in Itgb1^tm1Efu/Itgb1^tm1Efu Tg(Vil1-cre)997Gum/0 mice. A and B: Immunohistochemical detection of cleaved caspase 3 (brown; arrows) positive intestinal epithelial cells (IECs) in small intestine of control (wt) and Itgb1^tm1Efu/Itgb1^tm1Efu Tg(Vil1-cre)997Gum/0 (ko) mice. Bars, 0.05 mm. C-F: Transmission electron micrographs showing the basement membranes (arrows) in the ileum of control and mutant mice. SC, stromal cell; n, nucleus. G: Gastrointestinal tracts resected from mutant (top) and Itgb1^tm1Efu/Itgb1^tm1Efu (bottom) mice from Fig. 1E. H: The inset shows the larger diameters of the distal small intestine and proximal large intestine (black arrowheads) of the mutant mouse.

Copyright

This image is from Jones RG, J Cell Biol 2006 Nov 6;175(3):505-14, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:119155

Associated Alleles

Symbol	Name
Itgb1^tm1Efu	integrin beta 1 (fibronectin receptor beta); targeted mutation 1, Elaine Fuchs
Tg(Vil1-cre)997Gum	transgene insertion 997, Deborah L Gumucio

Associated Genotypes

Allelic Composition	Genetic Background
Itgb1^tm1Efu/Itgb1^tm1Efu Tg(Vil1-cre)997Gum/0	involves: 129X1/SvJ * C57BL/6J * SJL