Phenotype Image Detail

Image

Caption

Hematoxylin and eosin stained sections of the intestines of P14 control (WT) and Itgb1^tm1Efu/Itgb1^tm1Efu Tg(Vil1-cre)997Gum/0 mice (KO) littermates. Duodenal (A and B) and ileal (C and D) sections show markedly enlarged crypts (arrowheads) and villi (arrows) in the mutant mice (B and D) compared with those of the control littermate (A and C). m, muscularis layers. Normal crypts in the control mice are shown in the insets (A,C and E). Dysplastic crypts in the mutant mice are outlined by dashed lines (B,D and F). Sections through the cecum (large intestine) from a mutant mouse shows marked crypt hyperplasia (arrowheads in F) and dysplasia (dashed line) compared with a control littermate (E). Bars, 0.1 mm.

Copyright

This image is from Jones RG, J Cell Biol 2006 Nov 6;175(3):505-14, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:119155

Associated Alleles

Symbol	Name
Itgb1^tm1Efu	integrin beta 1 (fibronectin receptor beta); targeted mutation 1, Elaine Fuchs
Tg(Vil1-cre)997Gum	transgene insertion 997, Deborah L Gumucio

Associated Genotypes

Allelic Composition	Genetic Background
Itgb1^tm1Efu/Itgb1^tm1Efu Tg(Vil1-cre)997Gum/0	involves: 129X1/SvJ * C57BL/6J * SJL