Phenotype Image Detail

Image

Caption

A-D: Transverse jejunal sections from P6 control (WT, A) and Itgb1^tm1Efu/Itgb1^tm1Efu Tg(Vil1-cre)997Gum/0 (KO, B-D) littermates show polyps with stromal expansion (arrows) in mutant mice (C and D). The tissues were stained with glutaraldehyde and osmium tetroxide (A-C) or hematoxylin-eosin (D). E and F: Transmission electron photomicrographs of jejunal enterocytes show lipid inclusions (arrows) in a P6 mutant mouse (F) but not in the control littermate (E). G and H: Immunohistochemical detection (brown) of the apical membrane/brush border enterocytic marker NHE3 (arrowheads) in jejunal sections from P6 control (G) and mutant (H) mice. Insets show apical expression of NHE3. The insets show the apical membrane staining. I and J: Transmission electron photomicrographs of microvilli on the apical cell membranes of jejunal enterocytes show abnormal morphology and sizes of microvilli in a P6 mutant mouse (J) compared with a control littermate (I). Bars: A and B, 0.5 mm; C and D, 0.1 mm; G and H, 0.05 mm.

Copyright

This image is from Jones RG, J Cell Biol 2006 Nov 6;175(3):505-14, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:119155

Associated Alleles

Symbol	Name
Itgb1^tm1Efu	integrin beta 1 (fibronectin receptor beta); targeted mutation 1, Elaine Fuchs
Tg(Vil1-cre)997Gum	transgene insertion 997, Deborah L Gumucio

Associated Genotypes

Allelic Composition	Genetic Background
Itgb1^tm1Efu/Itgb1^tm1Efu Tg(Vil1-cre)997Gum/0	involves: 129X1/SvJ * C57BL/6J * SJL