Phenotype Image Detail

Image

Caption

Morphological defects in Foxo1^tm1Tf/Foxo1^tm1Tf mice. G and H: Comparison of the appearance of wild-type (Foxo1(+/+)) and Foxo1^tm1Tf/Foxo1^tm1Tf (Foxo1(-/-)) embryos, respectively, showed apparent growth retardation and a small first branchial arch, but no second branchial arch, and often remarkable pericardial swelling (arrow) in E9.5 mutants. I and J: Whole mount in situ hybridization with a Crabp1 antisense probe revealed the pathway of migrating crest cells populating branchial arches at E9.5. Specific staining in wild-type embryos can be seen in streams of cells migrating ventrally into the arches (arrows). The staining pattern in the mutant embryo was very similar to that in wild-type embryos. K and L: Shown is the hematoxylin and eosin staining of transverse sections at the level of the aortic arch. E9.5 mutant embryos had dorsal aortas that were severely underdeveloped and irregularly formed in addition to hypoplasia of branchial arches and unclear aortic arch arteries in contrast to wild-type embryos (arrowheads). The arrow shows the dorsal aorta. Scale bars: G and H, 300um; I-L, 150um.

Copyright

This image is from Furuyama T, J Biol Chem 2004 Aug 13;279(33):34741-9 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:92247

Associated Alleles

Symbol	Name
Foxo1^tm1Tf	forkhead box O1; targeted mutation 1, Tatsuo Furuyama

Associated Genotypes

Allelic Composition	Genetic Background
Foxo1^tm1Tf/Foxo1^tm1Tf	involves: C57BL/6J