Phenotype Image Detail

Image

Caption

A: Macroscopic appearance of wild-type (+/+) and Alox12b^tm1.1Krie/Alox12b^tm1.1Krie (-/-) mice at birth, and 2 and 3 hours after birth. Note the red, shiny skin and the dehydrated appearance of mutant mice. B: Dehydration assay over time. Data are presented as the percentage of initial body weight of wild-type (+/+, n=6), heterozygous (+/-, n=9) and homozygous (-/-, n=11) mutant mice. Only homozygous mutants showed a 10% weight loss/h. C: TEWL assay measured on ventral surface of newborn wild-type (+/+, n=9), heterozygous (+/-, n=18) and homozygous (-/-, n=15) mutant mice.

Copyright

This image is from Epp N, J Cell Biol 2007 Apr 9;177(1):173-82, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:134709

Associated Alleles

Symbol	Name
Alox12b^tm1.1Krie	arachidonate 12-lipoxygenase, 12R type; targeted mutation 1.1, Peter Krieg

Associated Genotypes

Allelic Composition	Genetic Background
Alox12b^tm1.1Krie/Alox12b^tm1.1Krie	involves: 129P2/OlaHsd * 129S6/SvEvTac * BALB/cJ * C57BL/6