Phenotype Image Detail

Image

Caption

A: Barrier-dependent dye exclusion assay on wild-type (+/+) and Alox12b^tm1.1Krie/Alox12b^tm1.1Krie (-/-) mice at the ages indicated. In control embryos, a decrease in skin permeability was observed from E16.5 to E17.5 as the barrier is acquired in the dorsal to ventral pattern, whereas mutant embryos remained completely stained. B: Lucifer yellow dye penetration assay of newborn wild-type and mutant mice. Dye penetration (green fluorescence) across the stratum corneum was observed in skin of mutant mice, but not in wild-type. Sections were counterstained with propidium iodide (red fluorescence). The dotted line shows the border of stratum corneum-stratum granulosum, the dashed line shows the epidermal-dermal junction. Bars, 20 um.

Copyright

This image is from Epp N, J Cell Biol 2007 Apr 9;177(1):173-82, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:134709

Associated Alleles

Symbol	Name
Alox12b^tm1.1Krie	arachidonate 12-lipoxygenase, 12R type; targeted mutation 1.1, Peter Krieg

Associated Genotypes

Allelic Composition	Genetic Background
Alox12b^tm1.1Krie/Alox12b^tm1.1Krie	involves: 129P2/OlaHsd * 129S6/SvEvTac * BALB/cJ * C57BL/6