Phenotype Image Detail

Image

Caption

A: Phenotypes of 18 day old Calr^tm1Mlk/Calr⁺ (crt^+/-) and Calr^tm1Mlk/Calr^tm1Mlk (crt^-/-) mouse fetuses are shown. The arrow indicates the umbilical hernia. Leg and tail biopsies were removed for better visualization of the defect and were used for DNA and protein analysis. B: Low magnification histology of 18 day old heterozygous and homozygous embryos are show. The arrow indicates the umbilical hernia. C: Phenotypes of wild-type (wt) and homozygous 12.5 day old mouse embryos. Sagittal sections of embryos were stained with hematoxylin and eosin.

Copyright

This image is from Mesaeli N, J Cell Biol 1999 Mar 8;144(5):857-68, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:53466

Associated Alleles

Symbol	Name
Calr^tm1Mlk	calreticulin; targeted mutation 1, Marek Michalak

Associated Genotypes

Allelic Composition	Genetic Background
Calr^tm1Mlk/Calr^tm1Mlk	involves: 129S4/SvJae * C57BL/6J