Phenotype Image Detail

Image

Caption

Phenotype of Lama3^tm1Crt/Lama3^tm1Crt mice. A: Newborn Lama3^tm1Crt/Lama3^tm1Crt (alpha3-/-) and wild-type (alpha3+/+) pups before blister formation. Arrow indicated reduced milk content in the stomach of the mutant pup. B: Progression of the phenotype in an affected pup 48 hours after birth. Blistering of the forelimbs and oral mucosa is shown. C: A 48 hour old mutant pup with severe blistering showing loss of epidermis over a significant percentage of the head and body. D: Milk in the gastrointestinal tract of the wild-type and mutant pup indicates that there is not an obstruction between the stomach and intestine (pyloric atresia) in mutant pups. The reduced stomach size and milk content was consistently observed in mutant pups. E: Front paw of a mutant pup in the early stages of blistering, ~6-8 hours after birth. The digits of the forelimbs are not detectable because epidermis has formed a cuff over the paw. F: Bleeding, indicated by the arrow, was frequently detected in the forelimbs of the mutant mice, even when blistering was not detectable.

Copyright

This image is from Ryan MC, J Cell Biol 1999 Jun 14;145(6):1309-23, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:55865

Associated Alleles

Symbol	Name
Lama3^tm1Crt	laminin, alpha 3; targeted mutation 1, William G Carter

Associated Genotypes

Allelic Composition	Genetic Background
Lama3^tm1Crt/Lama3^tm1Crt	involves: 129 * C57BL/6J