Phenotype Image Detail

Image

Caption

Histological analysis of skin and bone in the Thbs2^tm1Bst/Thbs2^tm1Bst mouse. A and B: Dermis from the back of a wild-type (+/+) mouse (A) and a Thbs2^tm1Bst/Thbs2^tm1Bst (-/-) mouse (B), stained with Verhoeff-van Gieson stain. Collagen fibers stain orange-red and epidermis, cells, and hair follicle stain yellow-brown. The collagen fibers in A form a wicker-like mesh but are largely oriented parallel to the epidermal surface. Collagen fibers in B appear disorganized and lack a predominant orientation parallel to the epidermal surface. Bar, 50 um. C and D: Mid-diaphyseal cross-section of the femur of a wild-type mouse (C) and mutant mouse (D), stained with hematoxylin and eosin. The increased cortical thickness and reduced marrow cavity of the femur from the mutant mouse are evident. The less regularly oval contour, and tendency to form a ridge, is a feature of the abnormal bone. Bar, 500 um.

Copyright

This image is from Kyriakides TR, J Cell Biol 1998 Jan 26;140(2):419-30, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:45509

Associated Alleles

Symbol	Name
Thbs2^tm1Bst	thrombospondin 2; targeted mutation 1, Paul Bornstein

Associated Genotypes

Allelic Composition	Genetic Background
Thbs2^tm1Bst/Thbs2^tm1Bst	either: (involves: 129S4/SvJae * 129X1/SvJ) or (involves: 129X1/SvJ)