Phenotype Image Detail

Image

Caption

B-G: Transmission electron microscopy of skin samples from Krt14^tm2Der/Krt14⁺ pups (B,C, and E-G) and normal littermate (D). The mutant pup skin showed keratin clumps and short keratin filaments in the basal keratinocytes (B,E-G), but normal keratin filaments in the suprabasal layer of the epidermis (B and C). Normal skin showed long keratin filaments in the basal keratinocytes (D). Kc, keratin clumps; Kf, keratin filaments; Kg, keratohyalin granules; Nu, nucleus. Small arrowheads denote hemidesmosomes, indicating the position of the basement membrane. Large arrowheads denote desmosomes. Bars: B, 5 um; C, 100 nm; D-G, 1 um.

Copyright

This image is from Cao T, J Cell Biol 2001 Feb 5;152(3):651-6, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:67320

Associated Alleles

Symbol	Name
Krt14^tm2Der	keratin 14; targeted mutation 2, Dennis R Roop

Associated Genotypes

Allelic Composition	Genetic Background
Krt14^tm2Der/Krt14^+	involves: 129X1/SvJ