Phenotype Image Detail

Image

Caption

Dyslamination in Foxc1^hith/Foxc1^hith mice. A and B: Tbr1 staining of P10 brains shows labeling of layers 2/3, 5, and 6 in control (Foxc1+/) and Foxc1^hith/Foxc1^hith (hith/hith) brains. The mutant brains are montages generated by merging two images of both brain hemispheres. In mutant brains Tbr1⁺ cells form heterotopic clusters in the marginal zone (blue arrows in Insets) and reveal significant disorganization of cortical layers (black arrows). C-F: Ctip2 staining labels cells in layers 5 and 6, and ER81 labels cells in layer 5, and both show significant laminar disorganization in mutant brains (black arrows); however, note that there are no Ctip2- or ER81-stained cells in the marginal zone.

Copyright

This image is from Zarbalis K, Proc Natl Acad Sci U S A 2007 Aug 28;104(35):14002-7. Copyright 2007 National Academy of Sciences, U.S.A. J:136459

Associated Alleles

Symbol	Name
Foxc1^hith	forkhead box C1; hole-in-the-head

Associated Genotypes

Allelic Composition	Genetic Background
Foxc1^hith/Foxc1^hith	involves: C57BL/6J * FVB/N