Phenotype Image Detail

Image

Caption

Electron micrographs of epithelial basal lamina (BLs) in the heads of control (B-E) and Lama5^tm1Jhm/Lama5^tm1Jhm (F-I) embryos at E8.7. A: Drawing indicating the approximate origins of the sections shown in B-I. The narrow line represents the BL. B and F: Lateral cranial surface ectoderm. C and G: Surface ectoderm near the dorsal midline. D and H: Junction of surface ectoderm and neuroepithelium. E and I: Neuroepithelium. BLs are intact in both mutants and controls beneath lateral ectoderm and neuroepithelium. BLs are discontinuous in both mutants and controls near the junction of ectoderm and neuroepithelium. Beneath the surface ectoderm near the neural folds, however, control BL is intact, whereas mutant BL is disrupted. This region of the ectoderm has been shown to be important in neural tube closure. n, neuroepithelium; se, surface ectoderm; arrowheads, BL. Bar, 0.5 um.

Copyright

This image is from Miner JH, J Cell Biol 1998 Dec 14;143(6):1713-23, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:51557

Associated Alleles

Symbol	Name
Lama5^tm1Jhm	laminin, alpha 5; targeted mutation 1, Jeffrey H Miner

Associated Genotypes

Allelic Composition	Genetic Background
Lama5^tm1Jhm/Lama5^tm1Jhm	involves: 129 * C57BL/6J