Phenotype Image Detail

Image

Caption

Morphology and histology of Col4a3^tm1Jhm/Col4a3^tm1Jhm kidneys. A-D: Kidneys from Col4a3^tm1Jhm/Col4a3^tm1Jhm mice (B and D) and littermate controls (A and C) at P36 (A and B) and P103 (C and D). Mutant kidneys are externally normal at P36 but shrunken and mottled at P103. E-J: Periodic acid Schiff-stained sections from mutant (F,H and J) and control (E,G and I) kidneys at P36 (E and F) and P79 (G-J). Renal histology is nearly normal at P36, but glomerulosclerosis (H, arrowheads in J), glomerular crescents (C), an expanded interstitium, proteinaceous glomerular deposits (arrow in H), tubular deposits (J), and tubular atrophy are evident at P79. Scale bar in J: E-H, 50 um; I and J, 100 um.

Copyright

This image is from Miner JH, J Cell Biol 1996 Dec;135(5):1403-13, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:37017

Associated Alleles

Symbol	Name
Col4a3^tm1Jhm	collagen, type IV, alpha 3; targeted mutation 1, Jeffrey H Miner

Associated Genotypes

Allelic Composition	Genetic Background
Col4a3^tm1Jhm/Col4a3^tm1Jhm	involves: 129S1/Sv * 129X1/SvJ