Phenotype Image Detail

Image

Caption

Skeletal phenotype of Bpnt2^{Gt(RST634)Byg}/Bpnt2^{Gt(RST634)Byg} mutant mice. A: E18.5 Bpnt2^{Gt(RST634)Byg}/Bpnt2^{Gt(RST634)Byg} (gt/gt, Right) mice exhibit shortened limbs compared with wild-type (WT, Left) littermates. B-E: Whole-mount preparations of wild-type and mutant E18.5 embryonic skeletons stained with Alcian blue (AB) and Alizarin red (AR). C: Isolated forelimbs of stained embryos depicting shortened scapula (s), humerus (h), radius (r), and ulna (u) in mutant mice compared with wild-type. D: Increased magnification of stained rib cages, ventral view. Note reduced spacing between ribs and length of sternum (st) in mutant mice. E: Dorsal view of wild-type and mutant AB/AR stained skulls demonstrating similar shape and size of parietal (p) and frontal (fr) bones between genotypes (outlined in black). Scale bars: 2 mm.

Copyright

This image is from Frederick JP, Proc Natl Acad Sci U S A 2008 Aug 19;105(33):11605-12. Copyright 2008 National Academy of Sciences, U.S.A. J:139706

Associated Alleles

Symbol	Name
Bpnt2^Gt(RST634)Byg	3'(2'), 5'-bisphosphate nucleotidase 2; gene trap RST634, BayGenomics

Associated Genotypes

Allelic Composition	Genetic Background
Bpnt2^Gt(RST634)Byg/Bpnt2^Gt(RST634)Byg	involves: 129P2/OlaHsd * C57BL/6