Phenotype Image Detail

Image

Caption

Histological analysis of Sgca^tm1Kcam/Sgca^tm1Kcam diaphragm muscle. Mutant mice started to develop a progressive muscular dystrophy at 1 week of age and, in contrast to Dmd^mdx/Dmd^mdx mice, showed ongoing muscle necrosis with increasing age. Examples of muscle pathology in the diaphragm of different aged mice are demonstrated. A: Myocyte atrophy (small fibers scattered throughout the micrograph) and central nucleation (see fibers near the center and in upper left quadrant) after regeneration in an 8 day old mouse. B: A small focus of myocyte necrosis (center) with surrounding regenerating and atrophic fibers in an 18 day old mouse. C: Skeletal muscle of a 4 week old mouse with ongoing necrosis (right of center), regeneration, central nucleation, endomysial fibrosis (increase in tissue between muscle fibers), atrophy, hypertrophy (large fibers in left lower quadrant), and fiber splitting. D: The edge of a large, confluent area of acute myocyte necrosis in an 8 week old mouse. E: More severe endomysial fibrosis with atrophy, central nucleation, fiber splitting, and dystrophic calcification (dark structures in lower right) in an 8 week old mouse. F: Small foci of myocyte necrosis surrounded by atrophic and hypertrophic fibers, central nucleation, and fiber splitting are showin in a 16 week old mouse. All panels show 7-um frozen sections of diaphragm muscle stained with hematoxylin and eosin.

Copyright

This image is from Duclos F, J Cell Biol 1998 Sep 21;142(6):1461-71, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:49992

Associated Alleles

Symbol	Name
Sgca^tm1Kcam	sarcoglycan, alpha (dystrophin-associated glycoprotein); targeted mutation 1, Kevin P Campbell

Associated Genotypes

Allelic Composition	Genetic Background
Sgca^tm1Kcam/Sgca^tm1Kcam	involves: 129S1/Sv * 129X1/SvJ