Phenotype Image Detail

Image

Caption

A: Lenses dissected from Gja8^tm1Paul/Gja8^tm1Paul mice at P14 were smaller than those of control littermates (B) and exhibited an irregular and diffuse nuclear opacity (A, arrow) not present in control lenses. By 6 months of age (C), mutant lenses had a fine particulate precipitate confined to the nucleus (C, arrow), characteristic of zonular pulverulent cataracts. In addition, a sharply defined line in the inner cortical region of the lens was present (arrowhead), the nature of which is not clear. D: 6 month old control lenses had no light scattering opacities. Bar, 1 mm.

Copyright

This image is from White TW, J Cell Biol 1998 Nov 2;143(3):815-25, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:50894

Associated Alleles

Symbol	Name
Gja8^tm1Paul	gap junction protein, alpha 8; targeted mutation 1, David L Paul

Associated Genotypes

Allelic Composition	Genetic Background
Gja8^tm1Paul/Gja8^tm1Paul	involves: 129S4/SvJae * C57BL/6J