Phenotype Image Detail

Image

Caption

Growth deficiencies and pathological changes in Gja8^tm1Paul/Gja8^tm1Paul lenses occur postnatally. Tissues were fixed, serially sectioned, and stained with hematoxylin and eosin. At E16.5, there were no differences in the size, or integrity of lenses from control (a) and Gja8^tm1Paul/Gja8^tm1Paul (b) embryos. At P7, control lenses had grown considerably, and the lens nuclei were stained with eosin throughout the lens (c), whereas mutant lenses were much smaller and exhibited a large clear zone in their nuclear region (d). At higher magnification (e), this clear zone was composed of fiber cells lacking the normal eosinophilic staining.

Copyright

This image is from White TW, J Cell Biol 1998 Nov 2;143(3):815-25, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:50894

Associated Alleles

Symbol	Name
Gja8^tm1Paul	gap junction protein, alpha 8; targeted mutation 1, David L Paul

Associated Genotypes

Allelic Composition	Genetic Background
Gja8^tm1Paul/Gja8^tm1Paul	involves: 129S4/SvJae * C57BL/6J