Phenotype Image Detail

Image

Caption

Morphology of placentas of Gjb2^tm1Kwi/Gjb2^tm1Kwi and wild-type embryos on 10.5 dpc. A: Overview of wild-type placenta showing the normal organization with chorionic plate, labyrinth (L), and spongiotrophoblast (S). B: Higher magnification revealed chorionic plate (CO), ingrowth of fetal stroma, and several fetal blood vessels (arrows) within the labyrinth (L). C: Overview of Gjb2^tm1Kwi/Gjb2^tm1Kwi placenta revealing the same organization of labyrinth, and spongiotrophoblast and decidua (D), as shown in A, but less extended than in wild-type placenta. D: Higher magnification showed a more compact labyrinth trophoblast with only few fetal vessels (arrow). Bars: A and C: 400 um; B and D; 100 um.

Copyright

This image is from Gabriel HD, J Cell Biol 1998 Mar 23;140(6):1453-61, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:46665

Associated Alleles

Symbol	Name
Gjb2^tm1Kwi	gap junction protein, beta 2; targeted mutation 1, Klaus Willecke

Associated Genotypes

Allelic Composition	Genetic Background
Gjb2^tm1Kwi/Gjb2^tm1Kwi	involves: 129P2/OlaHsd * C57BL/6