Phenotype Image Detail

Image

Caption

Toluidine blue-stained sections of the saccule of 5-6 week old wild-type (+/+, A) and Atp2b2^tm1Ges/Atp2b2^tm1Ges (-/-, B) mice. The macula (M), a neuroepithelial plaque containing the sensory hair cells and lying immediately beneath the gelatinous otolithic membrane (OM), appears histologically similar in mice of both genotypes. Innervation (open arrowheads) of the macula is also histologically similar in both genotypes. Otoconia (arrow), the calcium carbonate crystals embedded in the otolithic membrane, are absent in mutant mice. Scale bar, 50 um.

Copyright

This image is from Kozel PJ, J Biol Chem 1998 Jul 24;273(30):18693-6 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:48863

Associated Alleles

Symbol	Name
Atp2b2^tm1Ges	ATPase, Ca++ transporting, plasma membrane 2; targeted mutation 1, Gary E Shull

Associated Genotypes

Allelic Composition	Genetic Background
Atp2b2^tm1Ges/Atp2b2^tm1Ges	involves: 129/Sv * 129X1/SvJ * Black Swiss