Phenotype Image Detail

Image

Caption

Organ of Corti from 5-6 week old wild-type (+/+, A) and Atp2b2^tm1Ges/Atp2b2^tm1Ges (-/-, B-D) mice. The basilar (B) and tectorial (TM) membranes appear similar in all genotypes. Inner (IHC) and outer (OHC) hair cells and pillar cells (P) are identifiable in wild-type (A) and in the less affected regions of mutant (B) organ of Corti. More severely affected regions in the mutant show fewer identifiable cell types (C) or absence of identifiable component cells and architecture (D). Schwann cells and myelinated nerve fibers fill Rosenthal's canal (R) in the wild-type cochlear duct (A); nerve fibers in Rosenthal's canal of mutant cochlear ducts range from apparently normal (B) to greatly reduced (C) or virtually absent (D). The wide tunnel of Corti (T) typical of the wild-type organ of Corti (A) varies in regions of the mutant cochlear duct from wide to greatly reduced (B) or absent (C and D). Scale bar; 50 um.

Copyright

This image is from Kozel PJ, J Biol Chem 1998 Jul 24;273(30):18693-6 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:48863

Associated Alleles

Symbol	Name
Atp2b2^tm1Ges	ATPase, Ca++ transporting, plasma membrane 2; targeted mutation 1, Gary E Shull

Associated Genotypes

Allelic Composition	Genetic Background
Atp2b2^tm1Ges/Atp2b2^tm1Ges	involves: 129/Sv * 129X1/SvJ * Black Swiss