Phenotype Image Detail

Image

Caption

Histopathology of epithelia in Krt4^tm1Rak/Krt4^tm1Rak and wild-type littermate mice. Micrographs of Krt4^tm1Rak/Krt4^tm1Rak tissues are shown on the left, wild-type littermate control on the right. All tissues were formalin-fixed, paraffin-embedded, cut at 4 um, and stained with hematoxylin-eosin. The scale bar represents 20 um. A: Mutant, 2 months of age, esophagus. Note the distrurbed architecture and hyperplasia of the epithelium. B: Wild-type, 2 months of age, esophagus. Regular appearance of the esophagus. C: Mutant, 5 months of age, esophagus. Changes are apparent as in A, but more pronounced. Note the increased epithelial thickness and hemorrhagic exudate in the lumen. D: Wild-type, 5 months of age, esophagus. Regular appearance. E: Mutant, 5 months of age, cornea. Note hyperplasia and immaturity of the epithelial layers. F: Wild-type, 5 months of age, cornea. Regular epithelial appearance.

Copyright

This image is from Ness SL, J Biol Chem 1998 Sep 11;273(37):23904-11 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:49737

Associated Alleles

Symbol	Name
Krt4^tm1Rak	keratin 4; targeted mutation 1, Raju Kucherlapati

Associated Genotypes

Allelic Composition	Genetic Background
Krt4^tm1Rak/Krt4^tm1Rak	involves: 129/Sv * C57BL/6J * SJL