Phenotype Image Detail

Image

Caption

Histopathology of epithelia in Krt4^tm1Rak/Krt4^tm1Rak and wild-type littermate mice. Micrographs of Krt4^tm1Rak/Krt4^tm1Rak tissues are shown on the left, wild-type littermates on the right. All tissues were formalin-fixed, paraffin-embedded, cut at 4 um, and stained with hematoxylin and eosin (A-D) or specifically for PCNA by immunohistochemistry (E and F). The scale bar represents 20 um. A: Mutant, 5 months of age, ventral tongue. This micrograph shows a strikingly different epithelial architecture. B: Wild-type, 5 months of age, ventral tongue. Regular appearance. C: Mutant, 5 months of age, skin, Note the subcutaneous melanin deposits. D: Wild-type, 5 months of age, skin, Regular appearance and absence of subcutaneous melanin. E: Mutant, 5 months of age, esophagus, anti-PCNA immunohistochemistry. Note the presence of PCNA+ cells in all epithelial layers. F: Wild-type, 5 months of age, esophagus, staining as in E, PCNA+ cells are only present in the basal epithelial layer.

Copyright

This image is from Ness SL, J Biol Chem 1998 Sep 11;273(37):23904-11 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:49737

Associated Alleles

Symbol	Name
Krt4^tm1Rak	keratin 4; targeted mutation 1, Raju Kucherlapati

Associated Genotypes

Allelic Composition	Genetic Background
Krt4^tm1Rak/Krt4^tm1Rak	involves: 129/Sv * C57BL/6J * SJL