Phenotype Image Detail

Image

Caption

Cross-sections of testes (stage VII) from wild-type (A) and Spmap2^{Tg(PDE5A)1Ynk}/Spmap2^{Tg(PDE5A)1Ynk} mice (B) are shown. Staining with hematoxylin and eosin revealed abnormal elongated spermatids. The arrowhead indicates the increased intracytoplasmic vacuoles in elongated spermatids in mutant mice. Electron microscopy of the spermatids from wild-type (C) and mutant (D) mice. In mutant mice, dense fibers are shown to form a circular array (arrowhead). Bar, 2 um. E, quantitative evaluation of spermatogenic cells in seminiferous tubules (stage VII). The ratios of each type of spermatogenic cell to Sertoli cell per seminiferous tubule cross-section were calculated, and the obtained values were analyzed using a Dunnett-type multiple comparison test, with p <0.01 (**) as minimum significance.

Copyright

This image is from Yanaka N, J Biol Chem 2000 May 19;275(20):14791-4 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:62271

Associated Alleles

Symbol	Name
Spmap2^Tg(PDE5A)1Ynk	sperm microtubule associated protein 2; transgene insertion 1, Noriyuki Yanaka

Associated Genotypes

Allelic Composition	Genetic Background
Spmap2^Tg(PDE5A)1Ynk/Spmap2^Tg(PDE5A)1Ynk	involves: C3H