Phenotype Image Detail

Image

Caption

Whole mounts and histological analysis of E10 wild-type (A,C and E) and E9.5 Tmod1^tm1Vmf/Tmod1^tm1Vmf (Tmod -/-, B,D and F) embryos. Sagittal sections of wild-type (C and E) and mutant (D and F) embryos are shown. Severely underdeveloped myocardium and trabeculation (T) of the left ventricle are apparent in the mutant embryos (low and high magnification view in D and F, respectively) in comparison to wild-type (low and high magnification view in C and E, respectively). Note, in boxed in regions, complete lack of cellularization within the AV canal in mutant (F), in comparison to wild-type (E). V, ventricle; A, atrium; M, myocardium; DA, dorsal aorta; T, trabeculations; AV, AV canal; HT, heart.

Copyright

This image is from Fritz-Six KL, J Cell Biol 2003 Dec 8;163(5):1033-44, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:87158

Associated Alleles

Symbol	Name
Tmod1^tm1Vmf	tropomodulin 1; targeted mutation 1, Velia M Fowler

Associated Genotypes

Allelic Composition	Genetic Background
Tmod1^tm1Vmf/Tmod1^tm1Vmf	involves: 129S7/SvEvBrd * C57BL/6J