Phenotype Image Detail

Image

Caption

Photographic examination of the wild-type, Enam^tm1.1Jcch/Enam⁺ and Enam^tm1.1Jcch/Enam^tm1.1Jcch mouse dentitions at 7 weeks of age. Wild-type (Enam^+/+; top row), Enam^tm1.1Jcch/Enam⁺ (Enam^+/-; middle row) and Enam^tm1.1Jcch/Enam^tm1.1Jcch (Enam^-/-; bottom row) at 7 weeks. The color of the incisor enamel displayed an enamelin dose effect, with an increasingly chalky appearance with less enamelin expression (A-C). The mandibular and maxillary incisors of wild-type mice are brownish yellow in color (A). The mandibular incisors in the heterozygous mice are chalky white (B). The mandibular and maxillary incisors in the homozygous mice are both chalky white (C). The surfaces of the maxillary and mandibular incisors of wild-type mice (D and G) and the maxillary incisor of heterozygous mice (E) are smooth and unbroken. The surfaces of the maxillary and mandibular incisors of the homozygous mice (F and I) and the mandibular incisors of heterozygous mice (H) are rough and broken. The crowns of the first (M1), second (M2), and third (M3) molars were examined (J-L); the crown morphology of heterozygous mouse molars appeared normal, except for a subtle thinning and pitting of the enamel and hypoplasia of the M3 distal cusp (K). This contrasts with homozygous mouse molars (L), which showed altered cusp morphology due to enamel hypoplasia or aplasia and severe coronal wear into the underlying dentin.

Copyright

This image is from Hu JC, J Biol Chem 2008 Apr 18;283(16):10858-71 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:136524

Associated Alleles

Symbol	Name
Enam^tm1.1Jcch	enamelin; targeted mutation 1.1, Jan C C Hu

Associated Genotypes

Allelic Composition	Genetic Background
Enam^tm1.1Jcch/Enam^tm1.1Jcch	C57BL/6-Enam^tm1.1Jcch
Enam^tm1.1Jcch/Enam^+	C57BL/6-Enam^tm1.1Jcch