Phenotype Image Detail

Image

Caption

Histology of epididymis and testis of Lipe^tm1Ishi/Lipe^tm1Ishi mice. When compared with wild-type (+/+), Lipe^tm1Ishi/Lipe^tm1Ishi (-/-) epididymis contains no sperm but degenerated spermatocytes and spermatids. The thickness of the epithelial layers of the mutant seminiferous tubules was greatly reduced from 12 to 5-7 layers. The number of mature spermatids was also markedly reduced. Extensive vacuolation was observed in the epithelial cells. Epididymis, x50; Testis, X100.

Copyright

This image is from Osuga J, Proc Natl Acad Sci U S A 2000 Jan 18;97(2):787-92. Copyright 2000 National Academy of Sciences, U.S.A. J:59889

Associated Alleles

Symbol	Name
Lipe^tm1Ishi	lipase, hormone sensitive; targeted mutation 1, Shun Ishibashi

Associated Genotypes

Allelic Composition	Genetic Background
Lipe^tm1Ishi/Lipe^tm1Ishi	involves: 129S7/SvEvBrd * C57BL/6