Phenotype Image Detail

Image

Caption

A: Micro-CT 3D images of tibial metaphyses of 40 week old wild-type (+/+) and Tyrobp^tm1Ttk/Tyrobp^tm1Ttk (-/-) mice. Mutant mice showed increased bone mass. B: Hematoxylin and eosin staining of metaphysis sections from 6 week old wild-type and mutant mice. C: Percentages of trabecular bone volume per total tissue volume (BV/TV) of the femurs from wild-type (black bars) and mutant mice (white bars) at various ages. *P < 0.05. n=3. D: The numbers of TRAP⁺ multinucleated osteoclasts (OCs) in 6 week old wild-type and mutant mice are not significantly different. E: Transmission electron micrographs of in vivo osteoclasts from wild-type and mutant mice do not show significant differences. Mutant osteoclasts displayed a ruffled border (rb), a complex membrane structure, which is usually associated with active bone matrix resorption, and a clear zone (cz) attached to the bone matrix.

Copyright

This image is from Kaifu T, J Clin Invest 2003 Feb;111(3):323-32 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:81823

Associated Alleles

Symbol	Name
Tyrobp^tm1Ttk	TYRO protein tyrosine kinase binding protein; targeted mutation 1, Toshiyuki Takai

Associated Genotypes

Allelic Composition	Genetic Background
Tyrobp^tm1Ttk/Tyrobp^tm1Ttk	involves: 129P2/OlaHsd * C57BL/6