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Caption | A: Thalamus-accentuated reduction of myelin basic protein (MBP). Coronal brain sections were stained with anti-MBP antibody. The left side is from Tyrobptm1Ttk/Tyrobptm1Ttk (-/-) mouse and the right side is from wild-type (+/+) mouse, both at 3 months of age. Each panel is composed of multiple pictures. Arrow indicates the thalamus-accentuated reduction of MBP staining. fm, fimbria; ic, internal capsule; ptm, putamen, thlm, thalamus. Scale bar, 250 um. B-E: Ultrastructure of medial thalamus (B-D) and putamen (E). B: Lower-magnification views (original magnification: x2,000) of medial thalamus of 6 month old mutant and wild-type mice. Myelinated axons are reduced significantly in the mutant mouse, while blood vessels appear to be normal (arrow). C and D: Higher magnification views (x10,000 for C, x50,000 for D) showing many unmyelinated axons with aberrant morphology (arrows) and electron-dense appearance of the non-axonal area (C), and synaptic degeneration and abnormal accumulation of synaptic vesicles (flanked by arrowheads) in the mutant mouse (D). E: Putamen of 3 month old mice. Hypomyelinosis is not evident in this area, but a somewhat distorted axon shape is evident. Original magnification: x40.000. Scale bar, 250 nm. | ||||
Copyright | This image is from Kaifu T, J Clin Invest 2003 Feb;111(3):323-32 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:81823 | ||||
Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/02/2024 MGI 6.24 |
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