Phenotype Image Detail

Image

Caption

A: Thalamus-accentuated reduction of myelin basic protein (MBP). Coronal brain sections were stained with anti-MBP antibody. The left side is from Tyrobp^tm1Ttk/Tyrobp^tm1Ttk (-/-) mouse and the right side is from wild-type (+/+) mouse, both at 3 months of age. Each panel is composed of multiple pictures. Arrow indicates the thalamus-accentuated reduction of MBP staining. fm, fimbria; ic, internal capsule; ptm, putamen, thlm, thalamus. Scale bar, 250 um. B-E: Ultrastructure of medial thalamus (B-D) and putamen (E). B: Lower-magnification views (original magnification: x2,000) of medial thalamus of 6 month old mutant and wild-type mice. Myelinated axons are reduced significantly in the mutant mouse, while blood vessels appear to be normal (arrow). C and D: Higher magnification views (x10,000 for C, x50,000 for D) showing many unmyelinated axons with aberrant morphology (arrows) and electron-dense appearance of the non-axonal area (C), and synaptic degeneration and abnormal accumulation of synaptic vesicles (flanked by arrowheads) in the mutant mouse (D). E: Putamen of 3 month old mice. Hypomyelinosis is not evident in this area, but a somewhat distorted axon shape is evident. Original magnification: x40.000. Scale bar, 250 nm.

Copyright

This image is from Kaifu T, J Clin Invest 2003 Feb;111(3):323-32 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:81823

Associated Alleles

Symbol	Name
Tyrobp^tm1Ttk	TYRO protein tyrosine kinase binding protein; targeted mutation 1, Toshiyuki Takai

Associated Genotypes

Allelic Composition	Genetic Background
Tyrobp^tm1Ttk/Tyrobp^tm1Ttk	involves: 129P2/OlaHsd * C57BL/6