Phenotype Image Detail

Image

Caption

A and B: Photographs of 17 day old wild-type (Lmna^+/+, A) and Lmna^tm1Lgf/Lmna^tm1Lgf (Lmna^HG/HG, B) mice. The mutant mouse had a spontaneous fracture in the left forelimb (red arrow). C-F: Surface renderings of microCT scans of the skull (performed at exactly the same threshold) for a 17 day old mutant mouse (D and F) and littermate wild-type mouse (C and E). C and D: Top view of skulls. The mutant skull is misshapen, poorly mineralized, and exibits incomplete fusion of the cranial sutures (red arrow). E and F: Lateral view of skulls. The mutant skull is misshapen, with a small mandible (upper red arrow) and a short lower incisor (lower left arrow).

Copyright

This image is from Yang SH, J Clin Invest 2006 Aug;116(8):2115-21 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:113119

Associated Alleles

Symbol	Name
Lmna^tm1Lgf	lamin A; targeted mutation 1, Loren G Fong

Associated Genotypes

Allelic Composition	Genetic Background
Lmna^tm1Lgf/Lmna^tm1Lgf	involves: 129P2/OlaHsd * C57BL/6