Phenotype Image Detail

Image

Caption

Sections of proximal tibial and distal femoral epiphysis were examined in wild-type (A,C,E,G,I,L,O) and Dym^{Gt(GTR1.3)1Rul}/Dym^{Gt(GTR1.3)1Rul} (B,D,F,H,J,M,P,Q) mice at 2 weeks (A and B), 1 month (C-N), and 6 months of age (O-Q). Sections were stained with either Gomori's trichrome blue (A-D, O-Q) or safranin O (E-H), or were analyzed for BrdU incorporation (I and J) or for caspase 3 expression (L and M). Several islands of chondrocytes within ossified regions (*), and BrdU- and caspase-positive cells (arrows) are indicated. The graphs display the percentage of cells in the proliferative or hypertrophic zones that stained for BrdU incorporation (K) or caspase 3 expression (N), respectively.

Copyright

This image is from Osipovich AB, Proc Natl Acad Sci U S A 2008 Oct 21;105(42):16171-6. Copyright 2008 National Academy of Sciences, U.S.A. J:141099

Associated Alleles

Symbol	Name
Dym^Gt(GTR1.3)1Rul	dymeclin; gene trap 1, H Earl Ruley

Associated Genotypes

Allelic Composition	Genetic Background
Dym^Gt(GTR1.3)1Rul/Dym^Gt(GTR1.3)1Rul	involves: 129